Q&A with the doctor

Dr. Sheldon Saul Hendler Sheldon Saul Hendler,
Ph.D., M.D.
Dr. Joel M. Neutel Joel M. Neutel,
MD

The answers to the following questions are general. Because every individual is unique, you should consult with your own physician regarding how to best manage your blood pressure.

What is a dietary supplement?
Are there dietary supplements that can help maintain healthy blood pressure?
What is AmealPeptide®?
Can I take AmealPeptide® if I am already on prescription medication for my blood pressure?
Are there any side effects?
What would you recommend if my blood pressure is borderline?
When would I use a dietary supplement instead of a prescription drug?
If I fall into the prehypertensive range should I be concerned?
If I feel healthy does that mean that I don't have to worry about my blood pressure?
Is hypertension genetic?
How often should I get my blood pressure checked?
Should I try a dietary supplement before prescription medication?
How should I treat prehypertension?
What can I do in my daily life to help manage my blood pressure?
Can I take AmealPeptide® if I am lactose intolerant or have milk allergies?



What is a dietary supplement?
"A dietary supplement is a substance intended to supplement the diet and to support, maintain or promote good health. Dietary supplements contain one or more of the following ingredients: a vitamin, a mineral, an herb or other botanical, an amino acid, a peptide (a small chain of amino acids), or a concentrate, metabolite, constituent, extract, or combinations of these ingredients."

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Are there dietary supplements that can help maintain healthy blood pressure?
"The study of dietary supplements that support, maintain or promote healthy blood pressure is in its early stages. The most promising dietary supplements in this regard are small peptides that affect a central biochemical reaction in the major pathway for the regulation of blood pressure. AmealPeptide® is such a substance that can be found at your drugstore in ameal bp®."

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What is AmealPeptide®?
"AmealPeptide® is a naturally derived substance comprised of two small peptides, which are absorbed by the body when ingested. These peptides block a central biochemical reaction in the pathway that regulates blood pressure. Blocking this biochemical reaction may help to lower an elevated blood pressure, even at borderline elevated blood pressure. AmealPeptide® is derived from certain milk proteins. You should also know that some of the most important blood pressure-lowering drugs are also based on small peptides."

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Can I take ameal bp® if I am already on prescription medication for my blood pressure?
"Yes, however you must understand that ameal bp® is not a potent blood pressure-lowering substance. Therefore, if your blood pressure needs significant lowering in spite of the fact that you are already on a blood pressure-lowering medication, your doctor will likely add another potent blood-pressure lowering agent or switch you to a different medication to get your blood pressure under better control. However, if your blood-pressure needs just a little lowering to reach your desired blood pressure goal, then ameal bp® might be appropriate to take in addition to your medication. ameal bp® is not known to interact with any prescription medications."

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Are there any side effects?
"To date, no significant side effects have been observed in those taking ameal bp®."

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What would you recommend if my blood pressure is prehypertensive?
"If your blood pressure is prehypertensive, JNC 7 guidelines recommend initiating dietary changes (decrease your caloric intake, increase your intake of potassium, magnesium, and calcium-rich foods, and stop using the salt shaker), beginning a regular exercise regimen that you would stay on, if you are not already on one, and starting a trial of a dietary supplement that is supported by at least some credible clinical studies. A number of clinical studies performed suggest that ameal bp® might be a good candidate for the dietary supplement."

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When would I use a dietary supplement instead of a prescription drug?
"If your blood pressure falls in the prehypertensive range, between 120/80 and 139/89, or if you happen to be at risk for cardiovascular disease or stroke, even if your blood pressure is normal, I would recommend that you make the dietary changes I mentioned in the answer to your previous question and consider taking a dietary supplement that is backed by credible clinical studies."

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If I fall into the prehypertensive range should I be concerned?
"Research has shown that anyone with blood pressure levels slightly above normal (120/80) are at higher risk for hypertension and cardiovascular disease. The Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC) recently labeled slightly elevated blood pressure as prehypertensive so that people are aware that they need to start getting their blood pressure under control even if their blood pressure is only slightly elevated."

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If I feel healthy does that mean that I don't have to worry about my blood pressure?
"Many people with elevated blood pressure do not feel a thing but that does not mean that there is nothing to worry about. Even if your blood pressure is slightly above normal you are at higher risk for hypertension and cardiovascular disease. However, if you catch it soon enough, you can control your blood pressure with lifestyle changes such as maintaining a healthy diet, regular exercise, and possibly a dietary supplement."
 
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Is hypertension genetic?
"Hypertension is generally genetic. Anyone who has a family member with high blood pressure or hypertension is more likely to develop high blood pressure. However, that does not mean that you cannot control it with some lifestyle adjustments. If high blood pressure runs in your family make sure to get your blood pressure checked regularly and ask your doctor what you can do to help keep your blood pressure in a normal range."
 
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How often should I get my blood pressure checked?
"I recommend that you have regular annual exams, especially if you are over 35. If you are prehypertensive you should get your blood pressure checked every 4-6 months so that your doctor can monitor any significant changes and help you make adjustments to bring your blood pressure down to a normal range."
 
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Should I try a dietary supplement before prescription medication?
"Since many patients do not feel sick they do not want to take medication for their high blood pressure. However, many patients find a healthy diet and regular exercise routine hard to follow. Natural dietary supplements are much more acceptable to many patients. It is important that the dietary supplements used have been shown to be effective in good clinical studies. One such supplement that has been tested is ameal bp® that works like a drug without the side effects. AmealPeptide®, the naturally derived, active ingredient in ameal bp® has been tested in good clinical trials and provides prehypertensive patients with a natural alternative."
 
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How should I treat prehypertension?
"Treatment varies from one patient to another. I would be more aggressive with prehypertensive patients that also have high cholesterol, diabetes, heart disease, or a family history of any of these conditions. It is very important for these patients to maintain blood pressure levels at the low end of the healthy range. If a patient has slightly elevated blood pressure but no other risk factors I will recommend a good diet, regular aerobic exercise and advise them to come in often for checkups."
 
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What can I do in my daily life to help manage my blood pressure?
"It is important to maintain a low fat, low calorie diet high in potassium, magnesium, and calcium, and low in salt. You should also try to fit in thirty minutes of aerobic exercise four times a week. Some examples of aerobic exercise are: walking, dancing, jogging, bicycling, skating, swimming, yard work, house work. Even if you cannot find thirty minutes a day, any amount of physical activity is beneficial. In addition to a healthy diet and regular exercise, natural agents, with scientific basis that have been shown to lower blood pressure may be an alternative first step prior to starting antihypertensive drugs."
    
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Can I take AmealPeptide® if I am lactose intolerant or have milk allergies?
"There is no lactose in the product so that should not be a problem for those with lactose sensitivity. It is unlikely that anyone with milk protein allergies or sensitivities would have a problem using AmealPeptide®. AmealPeptide® contains extensively hydrolyzed casein, a milk protein, and therefore there are no milk proteins in the product. Milk proteins are the components in milk that those with milk allergies are allergic to. There are small peptides (chains of amino acids) in AmealPeptide®, but these small peptides are not likely to be a problem for those with milk protein allergies."
    
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Sheldon Saul Hendler, Ph.D., M.D.
Dr. Sheldon Saul Hendler is a physician-scientist, author and educator. He is the principal author and co-editor of the PDR (Physicians’ Desk Reference) for Nutritional Supplements, considered “the standard reference in the field” (New York Times). In addition to the PDR for Nutritional Supplements, he has written  a number of books and articles on nutritional supplementation, including the award-winning The Doctors’ Vitamin and Mineral Encyclopedia (Simon & Schuster, Publisher) and the award-winning The Complete Guide to Anti-Aging Nutrients (Simon & Schuster, Publisher),  the book that introduced the term anti-aging, and has published papers in the leading medical and scientific journals, including  The New England Journal of Medicine, Nature and The Proceedings of the National Academy of  Sciences. He is also Editor-in-Chief of the Journal of Medicinal Food (Mary Ann Liebert Publishers), an international, peer-reviewed and indexed journal. 

Dr. Hendler is a Clinical Professor of Medicine (Voluntary) at the University of California, San Diego and is a practicing Internist.  Dr. Hendler serves on the Scientific Advisory Board of the Dietary Supplement Education Alliance (DSEA) and is scientific and medical advisor to some of the major food, pharmaceutical and cosmetic companies. He is a Fellow of the American College of Nutrition and of the American Institute of Chemists. He was the Founding Chairman and Professor of Biochemistry at the Universidad Autonama de Baja California, was a member of the AARP Pharmacy Nutrition Advisory Board and was a member of the Scientific and Nutrition Subcommittee of the United States Olympic Committee. Dr. Hendler received his BS and PhD in Biochemistry from Columbia University, and his MD from the University of California, San Diego. 

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Joel M. Neutel, MD
Dr. Neutel has had long experience serving the biopharmaceutical industry in the areas of clinical and academic research, as well as marketing strategic planning.

Dr. Neutel maintains major responsibility as Director of Research at the Orange County Research Center in Orange, California and at the Memorial Research Medical Clinic in Long Beach, California, where he has served as Study Principal Investigator on many multinational cardiovascular trials. Dr. Neutel received his medical degree at the University of Witwatersrand in Johannesburg, South Africa. He completed his internship and residency in internal medicine at the Veterans Administration Medical Center in Long Beach and University of California, Irvine. Dr. Neutel has authored numerous abstracts, journal articles and book chapters. He has conducted extensive research in such disciplines as cardiovascular medicine, endocrinology, and central nervous system disorders, with special attention to the pharmacotherapy of the diseases in these areas.


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1 Suri, M F, Jawad F. Kirmani, M.D., Afshin A. Divani, Ph.D., and Yousef Mohammad, M.D. Prehypertension triples heart attack risk. Stroke Journal Report 5 Aug. 2005: 4 Dec. 2006. American Heart Association Web site. Available at: American Heart Association. Accessed December 4, 2006.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
ameal bp® is not a prescription drug and is not intended to replace your current medications. Consult your doctor before taking ameal bp®.
+For blood pressure already within the normal range.
"ameal bp" and "AmealPeptide" are registered trademarks of Calpis Co., Ltd., Tokyo, Japan.
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